Ambreen Tauseef, Ayesha Akmal, Zaima Ali.
Elevated Plasma Interleukin-10 levels in Dengue Hemorrhagic Fever.
Pak J Med Health Sci Jan ;8(2):288-90.

Aim: To measure the levels of plasma interleukin-10 in patients suffering from dengue hemorrhagic fever (DHF) between 4-7 days of onset of disease. Methods: In this cross sectional analytical study, a total of 50 diagnosed patients of DHF, 15-50 years of age of either sex, presented between 4 to 7 days of onset of disease were included. Plasma IL-10 levels were measured by using standard commercial enzyme- linked immunosorbent assay. Results: The mean plasma levels of IL-10 were observed to be elevated in all the subjects suffering from DHF but significantly higher in those patients who presented on 5th and 6th days of disease onset. More number of patients (65.2) were afebrile who presented on day 5th and 6th (representing defervescence phase), as compared to those who presented on 4th and 7th days of disease onset (35%). Conclusions: It is concluded that IL-10 levels are markedly elevated during the defervescence phase of dengue hemorrhagic disease, providing its potential role in the pathogenesis of disease.

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