Talha Mannan, Aizza Zafar, Naima Mehdi.
In Vitro Activity of Piperacillin/Tazobactam against Pseudomonas Species in Paediatric Population.
Pak J Med Health Sci Jan ;7(4):1143-6.

Aim: To determine the susceptibility of piperacillin/ tazobactam against Pseudomonas species Methods: This cross sectional observational study was conducted during April 2011 to March 2012 at Microbiology department of The Children’s Hospital and Institute of Child Health, Lahore. A total number of 10761 samples were collected and processed for microbiological investigations. The organisms were identified by routine laboratory tests including biochemical tests. Results: Out of 10,761 samples 2,375(22%) were positive for bacterial growth, among them 200(9.2%) were Pseudomonasspp. and 2,175(90.8%) were other than Pseudomonasspp. The highest proportion of Pseudomonas spp. was isolated from urine samples 69(34.5%) followed by blood 60(30%), swab 50(25%) and 21(10.5%) from the samples of sputum, secretion and tips. From a total 200 positive cultures ofPseudomonas spp. urology ward accounted for the highest proportion 44(18%), followed bymedical ward 36(18%). The proportions of other wards were as: OPD 30(15%), neonatology 29(14.5%), ICU 16(8%), hematologyoncology ward 14(7%), surgical ward 13(6.5%), developmental ward 7(3.5%), M/E 6(3%) and orthopedics ward 5(2.5%). Pseudomonas spp. was found highly sensitive to piperacillin/tazobactam (87.5%). Sensitivity to other antimicrobial discs was meropenem (86.5%), sulbactam/cefoperazone (82.5%), amikacin (74.5%), ciprofloxacin (64.5%), cefotaxime (17.5%), ceftriaxone (20.0%), ceftazidime (60.5%), pipemedic acid (21.75%), nitrofurantoin (18.8%) and norfloxacin (46.4%). Sensitivity of norfloxacin, nitrofurantoin. Conclusion: Piperacillin/tazobactam is the most active combination against Pseudomonas spp.and remains a very active beta-lactam when tested in vitro against clinical isolates of Pseudomonas spp.

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