Riffat Naseem, Safoora Aamir.
The Efficacy of Intralesional Measles, Mumps, Rubella (MMR) Antigen in Treatment of Common Warts.
Pak J Med Health Sci Jan ;7(4):1130-3.

Aim: To evaluate the efficacy of a new antigen combination measles, mumps, and rubella (MMR) antigen in the treatment of common warts. Methods: The study included 170 patients with single or multiple, recalcitrant or non-recalcitrant common warts both less and more than 6 months duration in all age groups. MMR antigen was injected into single lesions or largest wart in case of multiple lesions at 2-week intervals until complete clearance or for a maximum of 3 treatments. Follow-up was done every 2 weeks for one and half month to detect any recurrence. Results: There were total 170 patients on which 20 were lost or left the study in a period of 6 months. Multiple warts were observed in majority of patients 95(63.3%) irrespective of gender and age. As long as the response is considered regarding the injection therapy, most of the patients received 2 injections. There were some patients who showed just partial response up to 3 injections, those were of total 15(10%). Majority of the patients had warts on upper limb 65(43.3%). The final efficacy came as 81.3% which shows that a large number of (122) patients show complete response to the MMR vaccination. Conclusion: Intralesional immunotherapy by MMR vaccine came to be as simple, effective, and safe treatment for common warts. This study proved cost effective because in the previous studies patient is treated for long time but our result showed that same patient can be treated in 1 to 2 month with MMR vaccination with 3 injections. It is also evaluated that this treatment in also effective in local population and can be implemented.

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