Ayesha Anwar, Fatima Anwar, Saira Anwar, Muhammad Waqar Khan.
The Linkage of Gum Disease with Oncogenesis of Breast Tumor in Pakistani Women – a New Prospective.
Pak J Med Health Sci Jan ;7(4):945-7.

Aim: To find out the relation between Chronic Periodontitis and oncogenesis and to estimate the severity of disease and concentration of carcinogens in blood. Study design: Cross sectional study Methods: A total of 400 women, including 200 chronic periodontitis patients and 200 healthy controls between the ages of 30-40 years. Blood sample were drawn at the time of menstruation from all women and serum concentrations of 16α-hydroxyestrone and 17β-estradiol were measured by using standard Enzyme linked immunosorbent assay (ELISA) method. These parameters were compared in chronic periodontitis pts & age gender matched healthy controls to observe significance of difference. Results: Serum concentrations of these carcinogens in chronic periodontitis patients of Pakistan were statistically significantly elevated and were above normal reference value in chronic Periodontitis patients as compared to healthy controls. Chronic periodontitis has heavy influence at otherwise healthy women population and the probability of being at risk for cancer had appreciably increased.

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