Muhammed Iltaf, Jagdesh, Jai Parkash Panjwani, Mukesh Kumar Advai, Muhammed Yousif Memon, Khalil Ullah.
Trait Marker IGF1 is More Diagnostic than PSA in Ca Prostate, study at Local Population of Karachi.
Pak J Med Health Sci Jan ;7(3):626-9.

Aim: To evaluate the serum level of insulin like growth factor-1 (IGF-1) and prostate specific antigen in diagnosed prostate cancer patients and age matched normal healthy subjects in local population of Karachi and to compare the mean values of these parameters in CA prostate patients with normal control subjects and also to observe the sensitivity of these parameters. Methods: This study was carried out in the Department of Biochemistry, BMSI, JPMC, Karachi a total of 70 subjects were included with their consent in this study. 35 subjects were of prostate cancer and 35 normal age matched healthy control subjects for comparison. The diagnosed cases of prostate cancer were taken from Department of urology and Radiotherapy, JPMC, Karachi and control subjects were taken from general population. Results: The result showed that mean value of IGF-I in the control group was 190.60±5.59 and that of patient group was 230.68±4.25; showing statically significant difference (p <0.005). Whereas the PSA value in control and patient group were 0.83±0.10 and 63.35±9.78 with a highly significant difference p <0.005. The PSA value was found significantly high in patient group but when we sub-grouped these patients on the basis of PSA value (0-4ng/ml) we found that the majority of the cancer patients had raised PSA value, 30 out of 35(85.52%) had PSA value more than 4ng/ml, whereas 5 out of 35 (14.28%) although suffering from prostate cancer had PSA value within normal limit of less than 4ng/ml. The IGF-I value was found significantly high in patient group but when we sub-grouped these patients on the basis of IGF-I value we found that the majority of the cancer patients had raised IGF-I value, 33 out of 35(94.28%) had IGF-I value more than 200ng/ml, whereas only 2 out of 35 (5.72%) although suffering from prostate cancer had IGF-I value within normal limit of <200ng/ml. Conclusion: We strongly recommend serum IGF-1 level should be routinely done as a diagnostic biochemical tool along with PSA in carcinoma of prostate.

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