Sadiqa Batool.
Comparison of Oral Misoprostol for Induction of Labour in Primigravidas and Multigravidas.
Pak J Med Health Sci Jan ;7(1):239-42.

Objective: To compare the efficacy of oral misoprostol in primigravidas and multigravidas for induction of labour. Study design: comparative study Place and duration of study: Study was conducted at Gynae Department of Combined Military Hospital Tarbela for a period of one year from April 2010-April 2011. Materials and methods: Convenience sample of 100 pregnant women with singleton pregnancy, age group 22-35 years was taken. Primigravidas were labeled as group1 and multigravidas were labeled as group 2 Basic investigations and ultrasound for gestational age, amount of liquor was done. Bishop score was assessed prior to induction of labour. Inclusion and exclusion criteria were made for the participants in the study group. Participants in the study include primigravida and multigravida upto parity 4 was taken as inclusion criteria. Parity above 4 and previous scarred uterus cases were excluded. Results: Patients were divided in two groups including 50 in each one. Group 1 was primigravidas and Group 2 was multigravidas. Majority of the women in both groups were 22 to 35 years of age (72%) (Table 1). In group 1 86% had spontaneous vaginal delivery and 14% had lower segment caesarean section. In group 2 92% had spontaneous vaginal delivery and 8% had LSCS. Failed progress of labour, fetal distress and meconium stained liquor in both study group were indications for LSCS. The doses of misoprostol required in group1 were 3-4 doses and duration of labour was more than 18 hours in 24% of cases. While in group 2 90% of patients require only 2 doses and induction delivery interval was less than 18 hours in 50% of cases and more than 18 hours in 6% of cases. There was no case of uterine rupture, chorioamnionitis and puerperal sepsis. Conclusion: Oral misoprostol is found to be effective in induction of labour for different indications.

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