Azam Ali, Abdus Sattar, Amir Muhammad, Abdul Hameed, Muhammad Farooq.
Effect of Thyroid Hormone Replacement Therapy on Lipid Profile in Primary Hypothyroidism.
Pak J Med Health Sci Jan ;7(1):127-9.

Aim: To study the effect of thyroid hormone replacement therapy on lipid profile in primary hypothyroidism. Methods: Eighty subjects were recruited for this study. 40 patients (patient group before treatment G1) were treated with gradually increasing doses of “thyroxine” (50,100 and 150mg/day “doses adjusted by the treating physician”), each for 20 days to achieve a euthyroid state. Then 100-150 µg/day of thyroxine was given as maintenance dose for 30 days until the post therapy fasting blood sample from the same patients (patient group after treatment G2) was drawn. In control group (Group CG), 40 subjects age and sex matched euthyroid were selected. Study subjects were selected from the individuals who were referred to Atomic Energy Medical Centre (CENUM), Mayo Hospital Lahore. 40 subjects diagnosed as primary hypothyroidism (TSH >10µIu) with age range 18-40 years were selected. 40 with age and sex matched euthyroid subjects were selected as controls. The subjects having diabetes mellitus and ischemic heart disease were excluded. The individuals who were on any drug therapy that could alter lipid metabolism and thyroid function were also excluded. 10ml Antecubital venous blood samples were taken during morning hours (0800-1000), after an overnight fast (12-14 hours) and 30 minutes of supine rest. Serum was obtained for the thyroid profile. Results: Serum T3 level increased significantly in patients of primary hypothyroidism after treatment as it was compared with patient group before treatment. Serum T4 level increased significantly in patients of primary hypothyroidism after treatment when comparing with the patient group. Serum TSH level decreased significantly in patients of primary hypothyroidism after treatment when comparing it with the patient group before treatment. Serum TC, LDL-c, TG levels decreased significantly in patients of primary hypothyroidism after treatment as compared with serum TC, LDL-c, TG levels before treatment. Conclusion: Our results have proved the beneficial effects of L-thyroxine on the lipid profile of patients of primary hypothyroidism and showed the decreased TC, LDL-c & TG levels after treatment.

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