Farah Amir Ali, Rehana Khalil, Naila Perveen.
Comparison of High Sensitivity C Reactive Protein in subject with normal and low ankle brachial index.
Pak J Med Health Sci Jan ;7(1):64-6.

Objective: To compare high sensitivity C reactive protein in subjects with normal and low ankle brachial index. Methods: In a cross sectional observational study, 150 subjects were selected from either sex with age more than 45 years for males and 50 years for females along with conventional cardiovascular risk factors including hypertension, obesity, smoking and diabetes. The subjects were divided on the basis of basis of ABI >0.9 and <0.9 into two groups. The subjects were measured for BMI, lipid profile, serum glucose and hs CRP. ABI was taken from subjects in supine position after rest of 10 min by using hand held Doppler. Results: The levels of hs-CRP were significantly higher in group with low ABI <0.9 as compared to group with normal ABI >0.9 (p value is <0.001). A significant and positive correlation of both ABI and hs-CRP was observed with systolic blood pressure and pulse pressure. The correlation was non significant with diastolic blood pressure. The Pearson regression analysis showed significant negative correlation between hs-CRP and ABI. Conclusions: In our study we found negative correlation of ABI and hs-CRP which confirms the role inflammation in atherosclerosis. hs-CRP add predictive power to traditional factors for risk individuals.

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