Muhammad Ijaz Anwar, Muhammad Shafiq, Inayatur Rehman.
Anthropometric Measurements and their Association with Glycemic Parameters and Sex Hormones.
Pak J Med Health Sci Jan ;12(2):542-5.

Aim: To evaluate the association between body mass index, waist circumference and serum levels of insulin and insulin resistance and sex hormones levels in male offspring of type 2 diabetic parents . Methods: This cross-sectional, analytical study comprised of 80 subjects, 40 non-diabetic males (20-30 years of age) of single type-2 diabetic parents and 40 age matched healthy male controls without a family history of diabetes. For each participant, detailed medical history and clinical examination was performed. Fasting serum glucose, insulin, total testosterone, and sex hormone binding globulin levels were measured using standard kits. BMI and insulin resistance index were calculated. For data analysis, groups of young adults were matched using valid criteria for significance of difference. Results: Significantly higher values of body mass index (BMI) and waist circumference (WC), serum insulin and insulin resistance were observed in offspring of type 2 diabetics. On other hand mean sex hormone binding globulin levels were significantly low and an inverse correlation was found between serum SHBG and fasting blood glucose, serum insulin, insulin resistance, BMI and WC in study subjects. Conclusion: Offspring of type 2 diabetics with higher BMI and WC may exhibit hyperinsulinemia and lower levels of SHBG. Thus, higher levels of BMI and WC and their inverse correlation with SHBG and resultant hyperglycemic changes may predict the possible development of diabetes mellitus in offspring of type 2 diabetics.

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