Jehangir Mustafa, Syed Muhammad Javed Iqbal, Iqbal Ahamd Azhar, Muhammad Ashraf Sultan.
Nebulized Magnesium Sulphate as an Adjunct Therapy in the Management of Children Presenting with Acute Exacerbation of Asthma.
Pak J Med Health Sci Jan ;12(2):554-5.

Aim: To compare the mean SPO2 with nebulized magnesium sulphate as an adjunct with standard treatment versus placebo formanagement of children presenting with acute exacerbation of asthma Methods: This study was conducted in the Department of Paediatrics, Mayo Hospital, King Edward Medical University, Lahore, from October 2016 to March 2017. Total 100 cases were selected by non-probability, consecutive sampling. Children of age 5-12 years of either gender presenting with acute exacerbation of asthma of less than 6 hours duration were included, while children requiring immediate intubation and ventilation and children with complications of asthma on chest X-ray were excluded. Children were randomly divided in two groups by using computer generated random number table. All children received nebulization of salbutamol 3 times at 20 minutes interval. In group A, children were given additional nebuliazation with 3ml MgSO4 and in group B, children were given additional nebulization with 3ml of normal saline. All children were followed-up in ward for 90 minutes. Results: SPO2 was significantly higher in children who were nebulized with MgSO4. i.e., SPO2: MgSO4: 89.76 vs. Placebo: 82.52, (p-value= 0.000 ). Conclusion: Nebulized magnesium sulphate, as adjunct with standard treatment is effective in the management of children with acute asthma exacerbation.

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