Muhammad Kabir, Sara Sadiq, Abeer Raza, Sidrah Kanwal, Tamoor Tanvir.
Comparison of Efficacy of Adapalene (0.1% Gel) MonotherapyVeAdapalene (0.1%) Plus Benzyl Peroxide (2.5%) Combination Therapy for Treatment of Mild to Moderate Acne Vulgaris.
Pak J Med Health Sci Jan ;12(2):587-9.

Background:Acne is the most common disease of adult hood although no mortality is associated with it but it can result into drastic effects onone’s life if not treated properly. Among much different treatment options Adapalene is a 3rd generation retinoid that work by comedo lytic anti-inflammatory decrease sebum production improve scaring and pigmentation having role both in acute and maintenance phases. Aim: To compare the efficacy of adapalene (0.1% gel) monotherapy versus adapalene (0.1%) plus benzyl peroxide (2.5%) combination therapy for treatment of mild to moderate acne vulgaris. Methods: It was a randomized controlled single blind study carried out at Dermatology OPD of NHM. One hundred and twenty eight patients were included in the study. Patients were randomly allocated in to two groups by lottery method. Sixty four patients in group-A will be treated with adapalene (0.1% gel) pea sized amount of gel applied every night after washing face with a mild soap and benzoyl peroxide ( 2.5% gel) pea sized amount of gel applied every morning after washing face with a mild soap daily for 12 weeks and, 64 patients of group-B will be treated with adapalene (0.1% gel) pea sized amount of gel applied every night after washing face with a mild soap. Patients will be followed up on every 4th week and any side effect will be noted. Results: Of 128 patients, 60% were females and 40% were males. Mean patient age was 25.11+-3.116 years. Mean weight of patients was 58.36 +-5.047 kg. Effectiveness of those in group-A (combined therapy) was found to be 85.6% and those who were in group-B (monotherapy) showed 83.3% effective response. The effectiveness of both groups was compared by using chisquare test and shows p value was found to be 0.588. Conclusion: Comparison of efficacy of adapalene (0.1% gel) monotherapy versus adapalene (0.1%) plus benzyl peroxide (2.5%) combination therapy for treatment of mild to moderate acne vulgaris showed that there is no significant difference in both groups

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