Sana Nasir Bhalli, Muneeza Junaid, Haseeb Ahmed Khan.
Mean Platelet Volume (MPV): Usefulness in Ulcerative Colitis.
Pak J Med Health Sci Jan ;12(2):693-5.

Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease of unknown cause. The clinical course is characterized by exacerbations and remissions . Aim: To assess mean platelet volume as a non invasive and cost-effective bio marker of disease activity. Methods: It was a cross sectional study.180 patients of UC from Jinnah hospital Lahore were enrolled and their mean platelet volume was measured. Results: From 180 patients, the minimum age was 15 years and maximum age was 56 years with mean +- standard deviation as 36.71 +- 12.42 years. The minimum duration of ulcerative colitis was 2 months and maximum duration was 6 months with mean +-standard deviation as 4.00 +- 1.42 months The minimum mean platelet volume was 7.06 f13 and maximum age was 9.50 f13 with mean +-standard deviation as 8.49 +- 65 f13. There were 51.7% male patients and 48.3% females. 62.8% patients had active phase whereas 37.2% patients had remission phase . By using independent sample t-test, there was significant difference between phase of ulcerative and mean platelet volume. Conclusion: Mean platelet volume was significantly lower in patients with active phase than in remission phase of disease. Thus, MPV can be used as a cost effective and non invasive biomarker formonitoring disease activity.

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