Sadia Wazir Khan, Ammara Ghafoor, Nadia Ahamd.
Hepatoprotective Properties of Sugarcane Juice and Vitamin C were compared in a Mouse Model of Liver Injury Induced by INH (Isoniazid).
Pak J Med Health Sci Jan ;12(2):764-7.

Aim: To compare the hepatoprotective properties of sugarcane (Saccharum officinarum. L) juice and vitamin C in mice on hepatotoxicity induced by INH (Isoniazid). Methods: Ten mice were randomly placed in four groups A, B, C and D. Group A served as control, Group B received an oral dose of INH 100 mg/kg/day for 30 days and Group C was given sugarcane juice 15ml/kg/day along with INH 100 mg/kg/day orally for 30 days. Group D was given vitamin C 20mg/kg/day along with INH 100 mg/kg/day orally for 30 days. At the end of experimental period the animals were anesthetized and blood was obtained for the estimation of biochemical markers. The animals were then dissected and livers were taken and processed for microscopic examination. Results: Sugar cane juice showed histological regression of central vein congestion, periportal inflammation and vacuolar degeneration in hepatocytes. Simultaneously, sugar cane juice significantly lowered the raise in amino-transferases (ALT, AST) and alkaline phosphatase (ALP) levels, which show the liver functional status . Effects of vitamin C were less pronounced in terms of histological as well as biochemical evaluation. Conclusion: Sugarcane juice was found to be more effective as a hepatoprotective agent than vitamin C in INH induced oxidative liver injury.

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