Huma Ashraf, Uzma Jabbar, Naim Ahmad Nizami.
Serum Adiponectin and Leptin Levels in Obese and Non Obese Postmenopausal Women.
Pak J Med Health Sci Jan ;12(2):817-9.

Background: Increased adiposity in postmenopausal women may be responsible for increased synthesis of leptin and decreased production of adiponectin . Aim: To find out the levels of serum adiponectin and leptin levels as well as their correlation in obese and non obese postmenopausal women. Study design: Cross sectional study Methods: Study included 46 postmenopausal women with age > 50 years. Women were grouped as group A (Non obese), group B (obese). Women were chosen from Outdoor department of Lahore General Hospital Lahore. Level of serum leptin and adiponetin was estimated by the technique of ELISA. Women with BMI < 25 kg/m2 were taken as non obese and with BMI >25 kg/m2 were considered as obese. Results: It is observed that mean age of both obese and non obese women is 59 year. Values of BMI were significantly increased in obese menopausal women in comparison to non-obese menopausal women. Level of adiponetin was significantly decreased and leptin levels was significantly increased in obese women with menopausal status in comparison to non-obese menopausal women. A significant negative correlation of adiponectin with serum leptin was observed in non obese women in comparison with obese menopausal women. Conclusion: It is concluded that the reduced levels of serum adiponectin and increased levels of serum leptin may be the informative markers to evaluate the risk of hypertension, diabetes and dyslipidemia in obese postmenopausal women.

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