Muhammad Habeel Dar, Shiekh Fahad Falah, Imran Khan, Adnan Khan, Umair Ali.
Efficacy of valsartan plus amlodipine versus valsartan plus hydrochlorothiazide for control of moderate to severe hypertension: a randomized controlled trial.
Pak Heart J Jan ;50(1):39-45.

Objective: To compare of the efficacy of valsartan plus amlodipine versus valsartan plus hydrochlorothiazide for control of moderate to severe hypertension. Methodology: This randomized controlled trial was conducted at Department of Cardiology, Lady Reading Hospital Peshawar from 1 January, 2015 to 30 June,2015. All patients with stage 2 hypertension of either gender were randomly assigned into two groups. Patients in group A were subjected to combination of valsartan 160 mg plus amlodipine 10 mg and patients in group B were subjected to the combination of valsartan 160 mg plus hyrochlorothiazide 25 mg . Patients were selected by non probability purposive technique. All patients were followed for 4 weeks. Results: A total of 88 patients were included in this study. Mean age in both groups was 65+-1.26 years. In group A, 27(62%) patients were males, where asin group B, 26(60%) patients were males. Valsartan + Amlodipine was effective in 32(72%) cases and was not effective in 12(28%) cases while Valsartan + Hydrochlorothiazide was effective in 35(80%) cases and was not effective in 9(20%) cases (p=0.2). Conclusion: Both combinations had similar anti-hypertensive effects, however Valsartan + Hydrochlorothiazide combination had a better therapeutic profile asit showed fewer side effects and less treatment dropout than Valsartan + Amlodipine combination.

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