Muhammad Ilyas, Ikram Ullah, Farooq Ahmad, Umair Ali.
Corelation of body mass index with indices of diastolic function in normotensive, nondiabetic patients.
Pak Heart J Jan ;49(1):16-9.

Objective: To determine the association between body mass index and indices of diastolic function in normotensive and non-diabetics patients. Methodology: This cross sectional study was carried out at department of cardiology , Post Graduate Medical Institute Lady Reading Hospital Peshawar,from 1st March 2012 to 30th September 2012. Patients of either gender, age more than 40 years, who presented to cardiology OPD with cardiac problems other than heart failure symptoms were included. Patients BMI was calculated.Detailed echocardiographic study was done and EF, E' and E/E' ratio were calculated. Correlation between BMI and diastolic function parameters was assessed by multivariate logistic regression analysis and Pearson's correlation coefficient. Results: A total of 100 patients with mean age of 50.6 +- 4.62 years were enrolled. Of them 42% were males. The study sample was grouped into three according to their BMI: Group 1: patients of normal weight (BMI less than 25.0 kg/m ). Group 2: overweight patients (BMI between 25- 29.9 kg/m ) and Group 3were obese (BMI more than 30 kg/m ). Using Tissue Doppler Imaging (TDI) for diastolic function, E' was measured and E/+- ratio was calculated. Mean E/E' in group 1 was 8.10+-1.74, while E' was 7.67+-0.97 cm/s. Mean E/E' in group 2 was 8.84+-1.69 and E' was 6.54+-1.01 . E/E' in group 3 was 10.46+- 2.53 and E' was 6.23+-1.16 . Patient with higher BMI had lower E' wave(R =0.22; p=0.001) and higher E/E' ratio (R 0.14;p=0.002). In separate sub-analyses BMI had significant Correlation with lower E' ( 0.47, p <0.01) and higher E/E' ( 0.38, p <0.001). Conclusion: Higher BMI is a associated with worsening of diastolic function regardless of traditional risk factors for diastolic dysfunction. Key Words: BMI (Body Mass Index), Diastolic Dysfunction, E/E' Ratio, Obesity,Tissue Doppler Imaging, Early Diastolic Mitral Annular Velocity

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