Mudassar Noor, Usman Nawaz, Imran Fazal, Akbar Waheed.
Aspirin resistance: an emerging threat to cardiovascular disease patients and its association with age and gender.
Pak Heart J Jan ;51(2):119-23.

Objective: To examine the existence of pharmacological aspirin resistance and its association with age and gender in cardiovascular disease patients. Methodology: This cross sectional study was conducted from October 2015 to December 2016 at Pharmacology department Army Medical College, National University of Medical Sciences (NUMS), Rawalpindi in collaboration with Armed Forces Institute of Cardiology and National Institute of Heart Diseases (AFIC) and Armed Forces Institute of Pathology (AFIP), Rawalpindi. Platelet function was analyzed by light transmission aggregometry (LTA) using arachidonic acid as an agonist. Data was analyzed by using SPSS version 23.Chi-square test and students t test was applied to evaluate the categorical and numerical variables respectively. Results: Total of 384 cardiovascular patients meeting the explicit inclusion+-criteria were enrolled.+-There were 272 (70.8%) male and 112 (29.2%) female patients with the mean age of 48.22 +- 11.87 years. The statistical analysis revealed 13.8% (n=53) aspirin resistant cases in study population with 14.7 %(n=40) male and 11.6% (n=13) female (mean age 49.87+-13.20 years) were found to be aspirin non responders. Conclusion: Our study suggests that phenomenon of aspirin resistance does exist in Pakistani population, and it is not modulated by age and gender of patients.

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