Ayesha Sadiqa, Abdul Majeed Cheema.
Serum ratio analysis of CRP/IL-6 in patients of periodontitis and cardiovascular diseases.
Pak Heart J Jan ;52(1):75-9.

Objective: To explore the connection of periodontitis with cardiovascular diseases through ratio analysis of CRP/IL-6 in patients with both pathologies. Methodology: It was an cross-sectional study and involved participants of 30-70 year of age. All the subjects were broadly classified into three classes, selected by convenience sampling technique in to healthy controls, periodontitis patients and cardiac patients having periodontitis. Their Serum levels for C-RP and IL-6 was assessed through sandwich ELISA technique. One Way ANOVA as statistical tool, was used to measure the significant difference amongst studied groups. Results: About 95 participants were included with 56 males and 39 females.There were 21% healthy controls, 36% periodontitis and 41% cardiac patients.Females showed 1.7, 0.7 and 0.1 times raised serum ratio levels of CRP/IL-6 as compared to males, in cardiac patients with mild periodontitis, cardiac patients with severe periodontitis and mild periodontitis alone respectively. While in category of severe periodontitis, males exhibited 0.33 times more C-RP/IL-6 ratio concentrations in contrast to their counterpart females. Overall we found that with increase in periodontal and cardiac pathology, the ratio level of CRP/IL-6 is decreased in both genders separately and altogether, with significantly proved statistical difference (p<0.05). Conclusion: In both genders, with increase in pathology, serum ratio levels of CRP/IL-6 are decreased, also females exhibited more C-RP/IL-6 values in comparison to males with only periodontitis and periodontitis in addition to cardiac pathology.

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