Rukhshanda Jabeen, Tasnim Ahsan, Uzma Erum, Urooj Lal Rehman.
Pattern of Pituitary Lesions at the Endocrine Center of a Tertiary Care Hospital.
Pak J Med Res Jan ;58(2):88-92.

Objective: To study the frequency, demographic features, clinical presentation, radiological findings and treatment of patients with pituitary lesions, registered at the Endocrine Unit. Study type, settings and duration: A retrospective study was carried out at the Endocrine Unit of Jinnah Postgraduate Medical Centre, Karachi, from 2007 to 2014. Methodology: The retrospective analysis of case records of patients registered at tertiary care hospital, with different pituitary lesions was done. All the cases with definitive pituitary etiology were included in the analysis. Data was recorded in a pre-designed structured proforma. The frequency, demographic features, clinical presentation, radiological findings and treatment of patients with pituitary lesions were studied. Results: A total of 97 patients were diagnosed to have a definitive endocrine disorder related to the pituitary gland, of these 65 (67%) were female and 32 (33%) were male. The mean age was 32 +/- 11.5 years. The pattern of pituitary lesions was Prolactinoma in 26 (26.8%) patients, followed by Sheehan`s syndrome in 13 (13.4%); Acromegaly in 12 (12.4%); non-secretory pituitary adenoma in 11 (11.3%); Hypogonadotropic hypogonadism in 10 (10.3%) and Craniopharyngioma in 7 (7.2%) patients. Our study reported that pituitary lesions frequently affected female patients. Pituitary MRI showed pituitary tumor in 61 (62.9%) patients, of which macroadenoma was reported in 45 (73.7%) patients while microadenoma in 19 (31.1%) patients. Commonest clinical symptom was headache reported in 58 (59.7%) patients. Conclusion: Pituitary lesions frequently affected females, commonest being Prolactinomas. A high index of suspicion is required to appropriately evaluate the protean clinical symptoms of pituitary related disorders.

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