Ambreen Khan, Muhammad Taqi, Umer Farooq, Aamir Ali.
A Comparison of the Efficacy of Gabapentin and Diclofenac Sodium as Pre-Emptive Analgesia, for Post-Operative Pain Relief in patients Undergoing Major Abdominal Surgeries.
Pak J Med Health Sci Jan ;13(2):270.

Aim: To compare the efficacy of Gabapentin and Diclof enac sodium as pre-emptive analgesia, for post-operative pain relief in patients undergoing major abdominal surgeries. Study Design: Randomized control trial. Methods: This randomized clinical trial was conducted at Department of Anesthesia, DHQ teaching hospital Gujranwala, from January 2017 to December, 2017. Total 140 patients undergoing abdominal surgery, were included. Each patient was given cap. Gabapentin 600mg and tab. Diclofenac sodium 100mg along with sip of water one hour before shifting to opera tion theatre under my own supervision. All patients were anesthetized with standard general anesthesia protocol with same inducing agent. After completion of surgery and extrubation patient was shifted to recovery area adjacent to Operation Theater. Where pain was measured at 0 and 30minutes then patient will be shifted to ward and observed for 12hours. In ward pain was measured by VAS half hourly for 1st hour and then for 2 hourly 120, (2hours) 240(4 hours), 360(6hours) and 720(12hours) minutes after the surgery. Time interval between admission and patient’s first requirement for analgesic was noted. Along with the pain score ie VAS, HR, BP, SpO2 were noted. Results: In this study pain score at 0 and 30 th minutes was same in both treatment groups. However at 60 th minute patients in Group-A had better pain control as compare of Group-B patients as at this point 77% patients in Group-A and 67% in Group-B had no pain. (P-value (60 th Min) = 0.032) At 120 th minute 70% patients in Group-A and 64% in Group-B did not experienced any pain. From 240 th minute till 720 th minute pain control of patients was significantly better in Group-A as that of Group-B. Better control of pain status means that patient’s pain score was very low or very minor. Conclusion: The use of a single oral dose of Gabapentin is significantly effective as compared to diclofenac sodium when used as Pre-emptive analgesic for post-operative pain control. The effect not only lasts longer but it also reduces the need for rescue analgesia.

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