Jamil Akhter Munir Ahmad, Muhammad Ali Sheikh, Tariq Latif, Mukhtiar Ahmad, Muhammad Waseem Zia, Mehak Saleem.
Comparing Local Infiltration of Wounds with Bupivacaine and Intravenous Paracetamol in Paediatric Inguinal Surgeries.
Pak J Med Health Sci Jan ;13(2):318-22.

Background: Bupivacaine is quite effective in reducing post-operative pain in children and it helps to reduce the dosage of analgesia after operation. It contributes significantly to early mobilization and discharge from hospital thus reducing cost incurred by the patient. Aim: To evaluate and compare the efficacy of local infiltration of Bupivacaine in surgical clean wounds with i/v Paracetamol (acetaminophen) among children in early post-operative pain management in inguinal surgeries. Study design: It was double blind randomized clinical trial. Place and duration of study: This study was conducted in the Department of Paediatric Surgery, Shaikh Zayed Hospital, Lahore from July 2016 to July 2017. Methods: 140 patients were enrolled and divided in two groups. All relevant surgical steps were followed and in one group before closing skin 0.5% Bupivacaine (1 mg/kg) diluted in distal water and infiltrated in the incision, while in second group Paracetamol infusion was given intravenously during surgery. The pain score was measured in both groups of patients by applying the Face, Leg, Activity, Cry and Consolability scale (FLACC) 30 minutes after operation as base line and then after every 1 hour for the next 06 hours. Comparison at each hour interval for FLACC and duration without requirement of additional analgesia was performed between two groups by using independent sample T-test. Data for requirement of additional analgesia was described by using frequency and percentages for two groups and comparison was made by using Chi-Square test. Results: Age range in this study was from 2 to 60 months with mean age of 27.32+/-16.29 months. The mean age of patients in group A was 26.48+/-19.70 months and in group B was 28.51+/-19.18 months. In Group-A, 62(88.6%) were males and 8(11.4%) were female. In Group-B, 58 (82.9%) were male and 12(17.1%). It was also recorded that, there was a significant difference between groups according to additional analgesia given (p>0.001). Conclusion : Local infiltration of wound with Bupivacaine provides better and prolong analgesia than IV paracetamol in post-operative pain management.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com