Muhammad Rizwan, Rukhshanda Bajwa, Shazia N Ibnerasa, Muhammad Kashif Sarfraz, Seema Butt.
To study the Expression of Cyclin D1 in Renal Cell Carcinoma.
Pak J Med Health Sci Jan ;13(2):332-3.

Aim: To observe the expression of cyclin D1 as prognostic marker in different variants of (Renal Cell Carcinoma) RCC. Setting: Postgraduate Medical Institute, Lahore Methodology: Non-probability, Purposive sampling. Inclusion criteria : Histopathologically diagnosed cases of Renal cell carcinoma of all ages and both gender. Exclusion criteria: Patients already taking chemotherapy, radiotherapy or hormone therapy. Results : Patients of >50 years of age are mostly involved (53.8%) , with M:F ratio is 1: 1. Clear cell RCC is the most common type i.e. , 72(77.4%). As far as Cyclin D1 expression score is concerned, 60 (64.4%) cases having score 1 and 2 i.e. up to 30% +ve cells and 33(35.5%) cases having score 3 and 4. Conclusion : This study showed that the cyclin D1 protein is over expressed in RCC and that high protein levels were related to a better clinical result as well as to most of the good prognostic markers for RCC.

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