Haroon Habib, Yasir Ali Bhatti, Jhangir Zaib, Muzamil Liaqat Ali, Ali Iftikhar, Mudaser Hussain Abbasi.
Insight into the Hypoglycemic Effects of Traditional Herb- Berberis Vulgaris Methanolic Root Extract Supplementation among rats in Treatment of Cyclophosphamide-Induced Hepatotoxicity.
Pak J Med Health Sci Jan ;13(2):365-8.

Background: In the current study, 24 healthy adult male albino rats each having a weight in between 120-200g were used, acquited from The University of Lahore , Animal House. The Berberis vulgaris was fed to the Cyclophosphamide-induced hepatotoxic rats , resulting in a serious complication of hypoglycemia. However, there is hardly any evidence shows any improvement in glycemic control due to supplementation by Berberis vulgar is methanolic root extract . Aim: To accomplish a principal pharmacological screening contained in the aqueous extract of Berberis vulgaris and to discern the effects of hypoglycemia due to aqueous extracts on groups of rats rendered hepatotoxicity after injecting cyclophosphamide. Place of study: Study was conducted in the Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore. Duration of Study: 01 year from 01 January 2015- 31 December 2015 Methods: A retrospective cohort study was conducted from January 2015 to December 2015. Data were formulated into Microsoft Excel sheets Version 2013 and for analysis transferred to Statistical Package for Social Science (SPSS) version 22.0. A change in Hb was com pared by using Independent T-test. Lastly , to determine significance statistically, the p-values less than 0.05 and a 95% confidence level were used . Results: From a total of 24 albino rats , all were from Animal House of The University of Lahore. The mean change (+/-SD) of Hb from starting point to end of treatment was 13.35(+/-0.34) and 14.05 (+/-0.05 ) g/dl with and without Berberis vulgaris supplementation respectively , with a p-value of < 0.0001 that is clearly associated with the variation of Hb. Conclusion: Due to the positive effect of Berberis vulgaris root extract supplementation on the change of Hb , it can be recommended for an improved outcome in case of cyclophosphamide-induced hepatotoxicity .

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