Syed Nadeem Mansoor, Khawaja Amjad Hussain, Muhammad Ali 3 Rizwan Mehmood, Wajeeha Nadeem, Syed Moiz Nadeem.
Hematological Malignant Diseases in Pediatrics - a study of 342 children based on Bone Marrow.
Pak J Med Health Sci Jan ;13(2):373-5.

Aim: To identify frequency of different malignant hematological diseases in pediatric patients who were admitted in a tertiary care hospital of Lahore, Pakistan. Settings: Pathology Department of King Edward Medical University, Lahore from July 2009 to December 2014. Study Design: Study was retrospective. Methods: Files of children who were admitted with diagnosis of malignant hematological disease in oncology section of Pediatric Ward. Mayo Hospital , were studied retrospectively and important data regarding diagnosis was saved on a standard proforma. Bone marrow aspiration was performed in all children and trephine biopsy was done only in cases suspected of metastatic deposits in marrow or lymphomas. Results: During this study period number of bone marrow studies performed were 936. Three hundred forty two (36.5%) children were diagnosed and labelled as malignant disorders. Two hundred twenty two (6 5.0%) were male and 1 20 (35.0%) were female children. One hundred ninety two (57.5%) children were diagnosed as cases of acute lymphoblastic leukemia ( ALL) and fifty children (15.0%) as acute myelogenous leukemia. Conclusion: Our study concluded that acute lymphoblastic leukemia is the commonest malignant disorder and juvenile chronic myeloid leukemia (JCML) is the occasional and leastone.

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