Ambreen Khan, Aamir Ali, Umer Farooq, Muhammad Taqi.
Comparison of Midazolam & Propofol in Prevention of Sevoflurane Induced Emergence Agitation in Children Undergoing Inguinal Herniotomy and Circumcision.
Pak J Med Health Sci Jan ;13(2):379-81.

Aim: To compare the effect of midazolam and propofol in prevention of sevoflurane induced emergence agitation in children undergoing inguinal herniotomy and circumcision. Study Design: Randomized double blind trial. Methods: This randomized double blind study was conducted at Department of Anesthesia, DHQ teaching Hospital, Gujranwala from 10-01-2018 to 15-12-2018. In this study 268 healthy children were scheduled to undergo inguinal herniotomy and/or circumcision. The children were then allocated into two equal groups with random numbers by using a table generated by computer, the propofol group and midazolam group). Induction of general anesthesia was done with 7-8 % sevoflurane. Incidence of emergence delirium was measured by using Aono’s scale and proforma was filled. Results: In propofol group, the mean age of the patients was 4.70+/-2.38years. In midazolam group, the mean age of the patients was 4.79+/-2.44years. There were more males in study. In comparison of propofol with Midazolam the sevoflurane induced emergence agitation conditions were found to be statis tically significant postoperatively (P<0.1) and midazolam showed less emergence agitation.Conclusion: According to our study results midazolam is superior than propofol in prevention of sevoflurane induced emergence agitation in children who undergo surgery under general anesthesia.

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