Ruqaya, Jai Parkash Panjwani, Amar Lal Dodani, Tayyaba Kazmi, Ayesha Khan.
25(OH) Cholecalciferol an Important Player in the Progression of Neuropathy in Diabetic Case.
Pak J Med Health Sci Jan ;13(2):399-402.

Aim: To evaluate the role of vitamin D3 in nervous conduction studies of subjects suffering with diabetic mellitus. Methods: For this reason, the nerve conduction velocity was assessed in both healthy and diabetic subjects. Serum level of 25(OH) vitamin D and HbA1c were measured in both groups. 100 participants, 50 healthy and 50 diabetic subjects including both male and female were recruited for the study. The mean ages of male and female in control group were 45+/-2.54 and 42.34+/-8.61 years respectively; and the mean ages of males and females of diabetic subjects were 57.5+/-9 .92 and 49.87+/-8 .81 years. In the estimation of vitamin D3, the mean and standard deviation (SD) in diabetic subjects with neuropathy was significantly low 10.448+/-2.406 ng/ml as compared with diabetic subjects without neuropathy 25.821+/-4.417ng/ml. p<0.05 was taken as statistical significance value. Results: Serum level of Vitamin D3 showed a significant difference between control and diabetic subjects (P <0.01). Anthropometric measures included age, weight and height, was also recorded for both groups. The study has shown that along with duration of diabetes and elevated level of HbA1c, vitamin D3 was significantly associated with diabetic neuropathy. Conclusion: The insufficiency of vitamin D3 has an adverse effect in the development and progression of diabetic neuropathy. Therefore, Vitamin D supplementation is immediately required to preventor delay the development of neuropathy in diabetic Case .

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