Rao Salman Aziz, Khurram Munir, Adnan Bashir, Bilal Habib, Amna Mubeen, Nadar Ali Rana, Hassan Mahmood Makhdoom, Muhmmad Nadeem, Farah Naz Akbar, Faiqa Chaudhry.
Effects of Date Extract on Paracetamol induced Nephrotoxicity in Rabbits.
Pak J Med Health Sci Jan ;13(2):510-12.

Aim: To examine the effect of date extract on paracetamol provoke nephrotoxicity in Rabbits. 30 Rabbits were selected for this study; Methods: Rabbits were selected by random sampling for five stratum six rabbits in each stratum. They were kept under treatment for 14 days, The first stratum was control stratum no treatment given to rabbits. The second stratum was diseased stratum paracetamol given to rabbits of with pattern 2g/kg/day. Results: The rabbits of third stratum were treated date extract 400g/kg/day seven days before paracetamol administration. The rabbits of fourth stratum were treated with paracetamol 2g/kg/ day seven days before date extract administration. The rabbits of fifth stratum were treated 2g/kg/day along with date extract 400g/kg/day. The remarkable increase observed in serum urea and serum creatinine concentration in rabbits exposed nephrotoxic dose of paracetamol. The date extract treated rabbits show improvement in increased BUN and SC, Conclusion: The exposed rabbits were then treated with date extraxt and this led to improvement in recovery from the toxic insult. The date extract, in addition to this, also helped in preventing the nephrotoxicity.

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