Enam Elahi, Muhammad Ashfaq Ahmad, Shazia Mustafa.
Impact of Gallic Acid on Oxidative Stress in Diabetes.
Pak J Med Health Sci Jan ;12(1):80-2.

Background : Free radicals play important role in the metabolism of our body, free radicals transfer their free electrons, which result in the oxidation of cellular organization of human body. This oxidation process has detrimental effect on our body process, likewise in diabetes. Aim: To observe the result of Gallic acid on oxidative stress in diabetes. For that purpose the study was organized to understand the effect of Gallic on oxidative stress in alloxan induced diabetic rats and its effect on the control of diabetes. Methods: Fifteen adult male Wistar rats were selected and housed in steel cages in the animal farm at Rawalpindi Medical University, Rawalpindi during the period from 10.05.2016 to 20.05.2017. The rats were kept in the suitable environmental condition with the room temperature of 24 +/- 5 ℃, under a 12 hour light cycle : 12 hour dark cycle and were allowed free to have access to water and food (standard rats chow) (Amin et al. 2011). The rats were arranged into 3 different groups. Results: Determination of blood level of glucose showed that positive control group has significantly higher glucose level as compared to group treated with gallic acid. Determination of cholesterol concentration revealed no significant difference in cholesterol concentration was observed. Determination of serum triglycerides showed no significant difference. No remarkable changes were found in the case of HDL, LDL, and VLDL concentration. Conclusion: In the present study, it has been concluded that the GA has an ant diabetic potential. While their other properties like anti-lipidemic, antioxidants and anti-lipid peroxidation were not conformed during this research trial. Firstly, this is just because of that the potential dose of alloxan that was used in this dose is actually safe which showed no deterioration in major blood biochemistry instead of hyperglycemia.

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