Sadia Shakeel, Mariam Ashraf, Shagufta Nasreen, Fozia Farzana, Amna Ahsan, Muhammad Sharjeel Ilyas.
Histological Effect of Sodium Fluoride Gel on Buccal Mucosa of Albino Rats.
Pak J Med Health Sci Jan ;12(1):110-4.

Aim: Fluoride gels are being used abundantly among dental practitioners to treat tooth sensitivity and white spot lesions. Methods: This experimental study comprised of 30 Albino rats of average weight 200-250 grams which were divided into 3 groups. 10 out of 30 rats were randomly assigned into cont rol group A and rest of the 20 rats in experimental groups B and C containing 10 rats each. Animals of group B were topically treated with 0.2% sodium fluoride gel at a dose of 0.5mg/Kg as per body weight on buccal mucosa at day 1 for 4 minutes, with the help of cotton pellet. This group was sacrificed on the same day after half an hour of application of gel. The rest of the 10 animals of group C were given same dose of 0.2% sodium fluoride gel topically once daily for 4 minutes on buccal mucosa for 14 days and were sacrificed on 14th day under deep anesthesia. Results: Histological analysis showed that sodium fluoride gel used in the study produced apoptotic effects on buccal mucosa of albino rats with the toxicity increasing in a time dependant manner. Conclusion: Therefore there is a need not to use any type of fluoride gels in clinical practice as it may cause periodontal problems.

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