Nazia Rashid, Wardah Siddique, Zujaja Zaheer.
Evaluation of effect of Argyrolobiumroseum Aq. Extracton Carb. Tetrachloride induced liver in rabbits.
Pak J Med Health Sci Jan ;12(1):161-5.

Liver diseases are a matter of serious concern all over the world. They may lead to serious consequences such as cirrhosis and hepatocellular carcinoma. Many efforts are being made to discover new hpatoprotective agents. Herbal medicines are usually considered as safe and effective for various ailments. The therapeutic value of Argyrolobiumroseum has been recognized in traditional medicine. Hepatoprotective effect of aqueous extract Argyrolobiumroseum whole plant against CCl 4 induced hepatotoxicity was evaluated. In this study thirty five male rabbits were used. Animals were divided into five groups, containing seven animals in each group. Liver injury was induced by carbon tetra chloride 0.4ml/kg/day (1:1 in olive oil) in twe nty eight rabbits. Hepatoprotective effect of aqueous extract of Argyrolobiumroseum with doses of 200mg/kg/day, 400mg/kg/day and 600 mg/kg/day was evaluated. Serum AST, ALP, ALT and total bilirubin were evaluated by using Human CE kits in semi- automatic clinical chemistry analyzer, backmancoulter CX5. There was a significant elevation of Alanine transaminase (ALT), alkaline phosphatase (ALP), Aspartate transaminase (AST) and total bilirubin levels indicating development of hepatotoxicity. The level of ALP, ALT, AST and total bilirubin were significantly reduced (pvalue 0.001) in Argyrolobiumroseum (400mg/kg) treated rabbits showing the hepatoprotective effect of Argyrolobiumroseum .

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