Ambreen Khalid, Khalid Rahim Khan, Muhammad Humayoun, Amina Tahir.
Immunological and Hormonal Profile of Infertile Pakistani Males with Varicocele.
Pak J Med Health Sci Jan ;12(1):283-5.

Aims: To compare the levels of serum FS H, Testosterone in infertile men with and without varicocele and to detect the Antisperm antibodies (ASA) in the serum of infertile men with and without varicocele . Study Design &Settings : It is a Cross sectional prospective study the laboratory work was done at Physiology Department , University of Health Sciences, Lahore. Methods : This Cross sectional study was conducted on ninety patients that fulfilled the inclusion criteria. The patients were chosen from the infertile couples reporting to the Combined Military Hospital Lahore and General Hospital Lahore for infertility. Detailed history was taken meticulous physical examination and semen analysis of was performed on all the subjects. Scrotal ultrasound was done to confirm varicocele. Serum FSH, testosterone and antisperm antibody determination were carried out by ELISA. Results : Varicocele was found in 35 out of 99 infertile men by physical examination and confirmed by Scrotal Ultrasound. The infertile men with varicocele had higher levels of serum FSH than infertile men without varicocele. Levels of testosterone were lesser in subject with varicocele. All ( 99 ) infertile males with and without varicocele were subjected to ASA test. It was observed that out of 35 infertile men with varicocele was positive , while 3 out of 64 men without varicocele were positive for ASA. Conclusion : Our results suggest no relationship of varicocele with abnormal serum FSH & Testosterone levels and presence of ASA in infertile men with varicocele .

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