Muzamil Hussain, Muhammad Shahid, Muhammad Omer Ajmal.
Comparison of Efficacy of Lignocaine alone and Lignocaine Plus Metoclopramide for the Prevention of Intravenous Propofol Induced Pain in patients Undergoing G/A for Elective Surgical procedures.
Pak J Med Health Sci Jan ;12(1):319-22.

Aim : To compare the efficacy of lignocaine alone and lignocaine plus metoclopramide as pretreatment for the prevention of pain caused by the propofol injection in patients undergoing elective surgeries under general anaesthesia Methods: Hundred patients were included in this study and were divided into two groups, A&B, each having fifty patients. Each patient in both groups was educated about the procedure and verbal rating scale of pain. After attaching standard ASA monitoring devices and recording baseline heart rate, blood pressure, ECG and SpO2 , group A was given 10 ml of 1% propofol mixed with 1ml of 2% lignocaine and group B was given 10 ml of 1% propofol mixed with the mixture of1 ml of 2% lignocaine and 2ml of metochlopramide. Results: A statistically significant difference (p value= 0.000) was observed in the verbal rating score of both groups of patients. In group A, 80% (40 out of 50) of the patients remained pain free compared to 36%( 18 out of 50) patients )in group B, during propofol injection. Conclusion: The study has revealed that the lignocaine alone when mixed with propofol was more efficacious to reduce the pain caused by the propofol injection as compared to the combination of lignocaine and metoclopramide. This difference of efficacy was statistically significant.

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