Nida Gulzar, Anum Pari, Sadia Naeem, Shahwar Yousaf, Muhammad Shoaib Akhtar.
Prevalence of Hepatocellular Carcinoma in Hepatitis C patients.
Pak J Med Health Sci Jan ;12(1):334-6.

Background: The major risk for HCC is HCV and HBV among developed and under developed countries. The utmost cause of liver transplant among US population with HCC was also considered to HCV. The fibrosis stage plays an important role among chronic HCV patients and associated to HCC risk. Although the annual incidence of HCC is high in cirrhotic cases and lessly developed in less fibrosis livers. Methods: This was an observation cohort study where a total of 100 HCV patents were screened for HCC and risk factors associated. The exclusion criteria include all the patients with Hepatitis B and renal failure, whereas the patients with chronic Hepatitis C (HCV ) of both genders were included .. Results: The study cohort constitute of total of 100 patients, where all of them were HCV positive. The mean age of the patient was 42 +- 8.9. 62(62%) of the patients were males and 38(38%) were females. Most of the HCC patients were with elevated AFP. AFP has sensitivity, specificity positive predictive value and negative predictive values of 75%, 88%, 64%, 92% and 77%, 98%, 86%, 93% at cutoff value 100 and 200 ng/ml, respectively. Conclusion: The HCC was more prevalent among HCV patients and the leading causes were, positive family history, HBV comorbidity, jaundice and Hepatic encephalopathy.

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