Hassan Nawaz Dogar, Muhammad Haris Ghani, Hasiba Ilyas.
Hypothyroidism Screening in Menopausal Women - a Cross-sectional study at a teaching District headquarter Hospital in Punjab, Pakistan.
Pak J Med Health Sci Jan ;12(1):513-5.

Aim : To determine the frequency of hypothyroidism among menopausal women. Methods: In this descriptive cross-sectional study women aged 40- 55 years with signs and symptoms of menopause like hot flushes, depression, weight gain, sleeping problems,mood swings and cold intolerance were included. Females ha ving any gynaecological pathology, on hormonal replacement therapy (HRT) , with any bleeding disorder or history of using antiplatelet medication and with previous thyroid disorder were excluded from the study. Patient’s complete history and demographics were recorded. 2 ml of venous blood was collected from anterior cubital vein after an overnight fast under aseptic conditions from each individual with her consent. Serum was analysed via chemiluminescence immunoassay for TSH, T4 and T3 levels. Results: Ou tof total 100 females, hypothyroidism was found in 20(20%) women. Mean age of females was 49.78+/-4.65 years. The mean TSH, T3 and T4 of all the females was 3.26+/-2.91mIU/L, 2.13+/-0.64nmol/L and 98.31+/-30.49nmol/L respectively. Conclusion: Hypothyroidism is quite common amongst Pakistani perimenopausal women. There is a need to develop proper guidelines for routine screening of menopausal females for hypothyroidism as it is a potentially treatable condition with the help of thyroid hormone replacement therapy.

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