Hasiba Ilyas, Hareem Naw Az, Muhammad Zahid.
Contrast Induced Nephropathy in patients Undergoing Percutaneous Coronary Intervention.
Pak J Med Health Sci Jan ;12(1):520-2.

Aim : To determine the frequency of contrast induced nephropathy (CIN) amongst those who underwent percutaneous coronary intervention (PCI). Methods: In this descriptive cross-sectional study 100 consecutive patients who underwent PCI were enrolled. Patients of either gender aged between 30-70 years who underwent PCI (irrespective of whether primary or secondary) were included in the study. Those patients who were already on hemodialysis, received metformin, NSAID or aminoglycosides prior to the procedure, had abnormal RFTs before the procedure and who had undergone renal transplantation were excluded from the study .PCI was performed by a cardiologist having at least 3 years experience of performing independent PCIs. Low osmolar nonionic contrast media was used in angiography. Serum creatinine level was recorded at baseline and after 48 hours of angiography. Primary outcome for our study was CIN which was diagnosed as elevation of at least 0.5mg/dl in the serum creatinine concentration from base line up to 48 hours after administration of contrast agent. All the data was recorded on a pre- designed proforma and analyzed by SPSS version 21.0.p-value < 0.05 was taken as significant.Results: Out of total 100 cases, CIN was found in total 8(8%) patients. 4 diab etics (6.9%), 2 hypertensives ( 4.8%) and 7 of those with ACS (11.7%) developed CIN with difference in incidence rates being statistically insignificant (p-value = 0.41). Conclusion: CIN is a common complication following PCI, however there is no significant difference in incidence rates among different age groups, gender and risk factors.

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