Shahid Hussain Phul, Muhammad Mobushir, Rizwan-ul Ahsan Jilani, Imran Sikandar Khan, Rizwan Hameed Malik, Ghias Jan.
Comparison of Intra-Articular Steroids Injection Versus Platelets Rich Plasma Injection in patients with Osteoarthritic Knee Joints.
Pak J Med Health Sci Jan ;12(3):931-4.

Aim: To compare the mean pain between intra-articular steroids injection versus platelets rich plasma injection in patients with osteoarthritic knee joints. Methods: This randomized controlled trial was carried out at Department of Orthopaedics, Pakistan Institute of Medical Sciences, Islamabad from 20th February to 21st August 2015. Eighty patients presenting with knee joint OA were included. They were divided in two groups; Group A receiving platelets rich plasma (PRP) injection while group B receiving corticosteroid injection. Two hours before injection, a single dose of acetaminophen-codeine was given to the patients. Baseline and 3 months follow-up pain scores were recorded by asking patient to rate VAS as per the pain they feel on movement and outcome is difference of mean pain score. Results: There were male to female ratios were 1:2.4 and 1:1.8, mean ages were 54.45+/-4.54 years and 57.65+/-10.36 years and mean duration of symptoms were 1.93+/-0.57 years and 2.03+/-0.61 years in platelets rich plasma injection and corticosteroid injection groups. Statistically the difference between platelets rich plasma injection and corticosteriod injection groups were significant (P<0.05) in mean pain scores.Conclusion: It was found that platelets rich plasma is safe as well as effective technique for knee osteoarthritis treatment than intra-articular steroids.

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