Nasir Farooq Butt, Rabia Rathore, Hina Latif, Hassan Mehmood, Hafiz Saleem Faisal, Adil Iqbal.
Effect of Atorvastatin on Hematological Parameters in patients with Dyslipidemias.
Pak J Med Health Sci Jan ;12(3):1087-90.

Aim: To determine the effect of atorvastatin on hematological parameters in patients with dyslipidemia in order to reduce the cardiovascular risk. Study Design: Quasi-experimental study. Place and Duration of Study: Department of Medicine , Mayo Hospital Lahore from January 2017 to December 2017. Methods: 100 patients with treatment naïve dyslipidemia were included in the study. We investigated the effect of atorvastatin on hematological parameters i.e. mean platelet volume (MPV) , red cell distribution width (RDW) and Neutrophil Lymphocyte ratio (NLR) , which have an association with increased cardiovascular risk. Patients were prescribed 20mg of atorvastatin per day and were evaluated for above mentioned hematological parameters after 12 weeks. Paired t test was applied to compare pre- and post-treatment values of hematological parameters i.e. , MPV, RDW and NLR. P-value less than 0.05 was considered significant. Results: Total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and triglycerides levels decreased significantly from baseline to 12 weeks after treatment with atorvastatin. Levels of MPV showed reduction from 10.37+/-1.27 fl at baseline to 9.35 +/- 0.38 fl after treatment. (p<0.001). RDW levels fall from 14.46 +/-0.51% at baseline to 14.24 +/- 0.46 % after treatment. (p<0.001). NLR decreased from 2.82 +/- 0.25 at baseline to 2.73 +/- 0.25 after treatment. (p<0.001).Conclusion: Atorvastatin treatment significantly decreased cardiovascular risk makers like RDW, MPV and NLR in patients with dyslipidemia.

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