Shamsa Ijaz, Tahrim Ansar, Kanwal Saeed.
Changes in histopathology of liver of mice given altered doses of diclofenac sodium.
Pak J Med Health Sci Jan ;12(3):1177-8.

Diclofenac sodium belongs to the family of nonsteroidal anti-inflammatory drugs which is used to treat pain , inflammation and arthritis. The drug causes damage to various tissues due to oxygen reactive species formation . Following study is designed to evaluate the effects of altered doses of diclofenac sodium (6mg /kg body weight & 16mg/kg body weight) on histopathology of liver from 10-30 days. Administration of diclofenac sodium leads to degeneration of liver and formation of wide gaps called as sinusoidal fenestrations. Various stages of investigations revealed fibrosis of liver due to oxygen reactive oxygen species and inflammation. Maximum damage to the liver was observed due to degenerative changes. During later stages widening of sinusoids and necrosis was evident .

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