Khursheed Anwer, Qurrat-ul ain Mehfooz, Sana Tufail.
The Hepato-protective effect of Nigella sativa on Alcohol induced Hepatotoxicity in rodents.
Pak J Med Health Sci Jan ;12(4):1447-50.

Aim: To determine the effect of aqueous extract of Nigella sativa seeds in experim entally induced he patotoxicity by ethanol in rats. Study Design : Cohort study. Place of study: Animal research lab. Bakhtawar Amin Medical and Dental College, Multan Duration of study: From February 2018 To March 2018. Methods: The rats were separated in a control group (A), hepatitis induced group (B) while the leftover two groups(C and D) worked as investigational groups. They received "Nigella sativa" extract as hepatoprotective agent. Group C rats (experimental group Ι received 3g/kg body weight of ethanol as the intra-peritoneal injection and 250mg/kg body weight of "Nigella sativa" seeds extractorally daily. On the other hand group D rats (experimental group ΙΙ) received 3g/kg body wt of ethanol by intraperitoneal injections and aqueous seeds extract of "Nigella sativa" 500mg/kg body wt orally daily. Results: Blood samples were taken at the end of 6th week and liver was taken out for microscopical exam. The rats of experimental groups showed increase in ALT, AST, and ALP levels. 250mg/kg body weight of "Nigella sativa" seeds extract treatment diminished the level of these factors in rats. On the other hand 500mg/kg body weight of "Nigella sativa" dose considerably reduced levels of these biochemical factors. The histopathological investigation of experimental group Ι rats exhibited slight recovery whereas the rats in group ΙΙ revealed a substantial recovery. Conclusion: "Nigella sative " aqueous seeds extract showed hepato-protection against alcohol induced hepatotoxicity in rats in dose dependant manner.

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