Noman Tariq, Maqsood Ali, Tahir Nazeer, Riaz Hussain, Amna Tahir, Yumna Javaid.
Comparison of Ringer lactate Versus Hetastarch 6% to prevent hypotension in Spinal Anesthesia.
Pak J Med Health Sci Jan ;12(4):1729-31.

Background: In spinal anesthesia we inject local anesthetic in subarachnoid space and it causes sensory and motor block producing analgesia below the level of injection. It also produces hypotension. To prevent it we use fluid and vasopressors drugs. Aim : To compare the efficacy of ringer’s lactate versus Hetastarch 6% regarding prevention of spinal induced hypotension. Study Design : Randomized control trial. Methods : 160 patients undergoing elective surgeries under spinal anesthesia were selected and allocated into group A (Hetastarch 6%) and B (Ringer lactate) by using random number table. Each group comprised of 80 patients. Group A patients received 500 ml Hetastarch 6%. 15 minutes prior to surgery and group B received 1000ml Ringer lactate 15 minutes prior to surgery. Vital signs were noted every 3 minutes interval for 15 minutes and subsequently every 5 minutes up to 25 minutes of surgery. Results : Hetastarch 6% prevented 75% and Ringer lactate prevented 60% spinal anesthesia induced hypotension. Conclusions: Hetastarch 6% is better than Ringer lactate regarding prevention of hypotension due to spinal anesthesia.

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