Farukh Bashir, Zafar Iqbal Bhatti, Khawar Abbas Choudhery, Imran Yasin, Mujtaba H Assan.
Role of Vitamin D Supplements in Improving Fertility among Sub Fertile Couples.
Pak J Med Health Sci Jan ;13(1):28-32.

Background: Vitamin D is needed for calcium and phosphorus balance in body and for bone mineralization, vitamin D also plays a very important role in reproductive processes in both men and women. Aim: In women of reproductive age group, to evaluate the relationship between vitamin D and fertility in women. Study design and duration: Randomized controlled design from January 2014 to Feb 2017. Methods: Hundred patients with sub fertility were enrolled from OPD. Patients were randomly allocated for treatment and control group. Age, body mass index, type of infertility, etiology of infertility serum vitamin D levels, parameters of sperm count (quantitative variable, sperm progressive motility, typical form quantitative variable). Krugers criteria. Results: We found high prevalence of vitamin D insufficiency in our patients. Only 12 women out of 100 women (10.9%) who checked serum 25-(OH) vitamin D were sufficient. 88 Infertile women who were deficient in serum vitamin D (less than 30ng/ml) were included in this study. We treated 44 women with vitamin D supplements and 44 women received no supplementation. During the study the embryo transfer wasn’t done for four patients in the control group because of having thin endometrium until the 22nd day of the cycle. Additionally, it was not done for two patients in the experimental group because of no survived embryo after warming. 82 Final analyses consist of women with completed frozen thawed embryo transfer cycles. Clinical pregnancy rate in control group women was 20% and in experimental group it was 43%. Conclusion: While comparing PCOS women who took vitamin D supplements and those with deficiency of vitamin D, women with supplements have improve menstrual frequency, and have less metabolic disturbances.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com