Saman Saeed, Umer Saeed, Naveed Shuja, Sana Hasan.
Serial Evaluation and Interelationship of C- Reactive Protein and Cardiac Enzymes Pattern in patients of Ischemic Heart Disease Undergoing Coronary Artery Bypass Surgery.
Pak J Med Health Sci Jan ;13(1):161-5.

Background: Coronary artery disease (CAD) is one of the leading causes of deaths in Pakistan. The relationship of CRP (C-reactive protein) with the mechanism of CAD involves a slow progression of atherosclerosis in the coronary arteries followed by myocardial necrosis. CRP has been considered as a vital bio-marker of inflammation. Elevation of high-sensitivity CRPis associated with grave prognosis in patients suffering from CAD. Aim: To assess the serial measurement of plasma CRP levels and cardiac enzymes in adult patients of both sexes known to have CAD undergoing coronary artery bypass graft surgery (CABG), and correlate the findings. Methods: The study involved a total of 60 adult people, 30 of them were diagnosed cases of CAD, scheduled for CABG (n=30), while other 30 were healthy control subjects (n=30). Blood samples equal to 5 ml were collected after written consent and serum was obtained from the obtained samples. Serial estimations cardiac enzymes and CRP levels were performed in both cases and control subjects, by using immuno-turbidometric assays. Results: Plasma levels of CRP were significantly higher in patients of CAD, compared with control subjects. The estimated marginal mean of CRP levels before the bypass graft surgeries was significantly higher. The levels were observed to decrease after 2nd, 3rd and 4th postop days, and levels were equal to normal after 5th postop day Conclusion: Average plasma levels of CRP in patients of CAD were approximately 7 mg/dl, but after the CABG surgery, plasma CRP levels decreased significantly till 4th post-operative day. There was no association between the CRP levels with the plasma levels of cardiac enzymes CK-Mb (Creatine Kinase MB fraction), AST (Aspartate Transaminase) and LDH (Lactate Dehydrogenase) on the 4th post-operative day.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com