Arz Muhammad, Asma Nizam, Muhammad Hannan Yousuf, Haseeb Kamran.
Angiographic Severity of CAD in patients with Acute Coronary Syndrome in Correlation to their Glycemic Status.
Pak J Med Health Sci Jan ;13(1):312-6.

Background : Atherosclerotic vascular diseases, which comprises coronary heart disease and cerebrovascular disease is a major global health burden. Diabetes is considered as an independent risk factor for coronary artery disease and cardiovascular diseases. Aim: To assess the severity of CAD by coronary angiography in pre-diabetic, diabetic and non-diabetic patients presenting with acute coronary syndrome. Method: A total of 412 patients admitted with acute coronary syndrome in the study period who subsequently underwent coronary angiogram were included in the study that satisfied the inclusion and exclusion criteria.All patients were medically stabilised and subjected to coronary angiogram as an when it was indicated. The angiographic severity of the coronary artery disease was assessed using the Gensini score. Results: The severity of CAD was higher in Diabetics with a mean gensini score of 47.1, followed by Pre diabetics with 41.5 and Non diabetics with comparatively lower involvement of severity of CAD with a mean gensini score of 38.5. (P value 0.049) . The severity of CAD was higher in patients with diabetes for more than 5 years. There was statistically significant correlation between the duration of diabetes and severity of CAD in diabetics Conclusion: Diabetics had greater severity of CAD compared with pre diabetics and non diabetics although there was no significant correlation between level of glycemic control and severity of CAD.

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