Rabia Mohsin, Asma Saeed, Muhammad Mehtab Baig, Mohsin Khan.
Role of Letrozole and Metformin Vs Letrozole Alone in Ovulation Induction in Polycystic Ovarian Syndrome.
Pak J Med Health Sci Jan ;13(1):350-1.

Aim: To compare letrozole and metformin with letrozole alone, in ovulation induction in terms of pregnancy rate in infertile polycystic ovarian syndrome patients. Study Design: Randomized Controlled Trial from March-2018 to Jan-2019. Setting: Obstetrics and Gynaecology Department of CMH Multan. Methods: A total number of 100 females with diagnosis of polycystic ovarian syndrome (PCOS) having age 20-35 years were included in this study. In group A; tablet metformin along with letrozole (LE; 2.5 mg) was given 500 mg three times daily with meals starting from the first day of cycle and continuous for three cycles and to be stopped when pregnancy is achieved. In both group; 2.5 mg twice daily LE was administered on 3rd day of menses and then every day for 5 days. Patients were followed for 3 months to evaluate pregnancy. Results: Mean age of patients was 28.51+/-4.63 years. Mean duration of infertility in(PCOS patients was 3.13+/-1.20 years. On comparison of pregnancy between the groups, the pregnancy was achieved in 41 patients in who letrozole alone was given versus 56 in females in whom letrozole plus metformin was given (p-value 0.03). Conclusion: Combination of letrozole plus metformin is superior as compared to letrozole alone for induction of pregnancy in female patients with polycystic ovarian syndrome.

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