Amna Shujaat Ali Naqvi, Zujaja Hina Haroon, Qurat-ul Ain, Muhammad Aamir, Sobia Irum Kirmani, Muhammad Tahir Khadim.
Assessment of macroprolactinemia and its role in diagnosis of hyperprolactinaemia.
Pak J Pathol Jan ;30(3):76-8.

Objective: This study was conducted with objective to determine the macroprolactin levels after polyethyl glycol (PEG) treatment. Material and Methods: This was a descriptive cross-sectional study and conducted in Armed Forces Institute of Pathology (AFIP) Rawalpindi for a period of six months from Jan to June 2019. Female patients presenting to tertiary care hospital with prolactin levels more than 1000 mIU/L were included in the study. An inclusion criterion was thus defined as patients within reproductive age and level of prolactin more than 1000mIU/L. While patients with gestational amenorrhea, patients on chronic medication, hyperthyroid or hypothyroid and patients with diagnosed case of any cancer were excluded from this study. Sample was collected in yellow topped gel tube that was centrifuged and analysed before and after PEG treatment. Results: In current study total 136 samples were included for measuring macro prolactin levels. All these samples were analyzed for prolactin before and after Polyethylene glycol (PEG). Test of normality (Kolmogorov, s and simrnov test) was run to check whether data was parametric or non-parametric and it proved data to be non-parametric. Median age was 35 years. Prolactin in untreated samples ranged from 1089mIU/L to 66000 mIU/L while after treatment with PEG (6000) ranged from 92 mIU/L -4700 MIU/L. Out of 136 patients 79 (58 %) showed macroprolactinemia while 57 (42 %) had true hyperprolactinemia. Conclusion:This study concluded that macroprolactinemia occur in significant number of cases leading to false over diagnosis of hyperprolactinemia.

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