Hafiz Muhammad Hamid, Sarmad Masud, Aamir Waseem, Aamir Bashir, Asma Samreen, Saima Ashraf.
Effect of Priming Principle on Propofol Dose Required to Induce General Anesthesia.
J Bahria Uni Med Dental Coll Jan ;10(1):40-3.
Objective: To compare the mean induction dose of Propofol to induce general anesthesia by conventional method versus mean induction dose after applying priming principle. Study Design and Setting: Randomized controlled trial at Operation theatre complex, Shalamar Hospital, Lahore from November 2016 to May 2017. Methods: A total of 100 patients aged 18-55 years were equally divided into control and study groups. After standard anesthetic monitoring, intravenous propofol was used for induction of general anesthesia by conventional method in Control (C) group and by applying Priming principle in Study (S) group. Total dose requirement of propofol was noted. Data was analyzed in SPSS version 20 and paired sample t-test was applied. P-value of < 0.05 was considered as significant. Results: The mean induction dose of propofol was 70.90 +- 16.77 mg in study group (S) as compared to 94.60 +- 20.22 mg in the control group (C). The difference of mean induction dose in both groups was 23.7+- 3.45 mg and thus p-value of 0.000. Conclusion: There was significant reduction of dose of propofol required to induce general anesthesia in elective surgical patient by applying priming principle.
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