Muhammad Sadiq, Saima Jabeen, Yousaf Jamal Mahsood, Farah Akhtar.
Pharmacological Aspects and Utilization of Topical Antiglaucoma Drugs.
Al-Shifa J Ophthalmol Jan ;14(1):34-43.

Objective: To evaluate the utilization of topical antiglaucoma eye drops at a tertiary care teaching eye hospital. Subjects and Methods: Data was obtained from computer record of the hospital and included only quantities and brand names of eye drops utilized and dispensed at main pharmacy of the hospital. The data was reorganized and rearranged by taking help from Pharma Guide Pakistan (23nd Edition, 2014-15) for active ingredients, Company name and drug group. The antiglaucoma drugs were then segregated from the whole data and then divided into six groups. All of the groups and individual drugs were analyzed with respect to their utilization pattern during three years and their pharmacological aspects were discussed and reviewed by using Google scholars and PubMed research data base. The patients who purchased eye drops from other than hospital pharmacy were excluded from this study. Results: Amongst antiglaucoma groups fixed dose combinations (including dorzolamide HCl + Timolol maleate and Latanoprost + Timolol maleate) were utilized highest in number 49082 units {1363.4 average/month (34.70 %)} during three years, followed by Beta receptors antagonists 34045 {945.7 average/month (24.07 %)}, then alpha 2 adrenergic receptors agonists 28833 units {800.9 average/month (20.39 %)}, prostaglandin analogues 22799 units {633.3 average/month (16.12 %)} and parasympathomimetics (miotics) 4630 units {128.6 average/month (3.27 %)}. Carbonic anhydrase inhibitors were the lowest utilized antiglaucoma topical drugs 2051 units {57 average/month (1.45%)} during three years (July 2012-June 2015). Conclusion: It was concluded that fixed dose combinations (FDC) were the most utilized antiglaucoma eye drops and amongst single drug the timolol maleate was the highest utilized antiglaucoma drug.

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