Hafsa Qamar, Muhammad Asif Siddiqui, Faiqa Saleem, Muhammad Zaki Mughal.
To Determine the Efficacy of Diosmectite in Children with Acute Gastroenteritis.
Esculapio J Services Inst Med Sci Jan ;13(4):188-91.

Objective: To determine the decrease in mean duration of diarrhea and normalization of stool consistency by smectite in children with acute gastroenteritis. Methods: A total of 300 patient children aged 1-12 years old fulfilling inclusion criteria were sorted in two groups; 150 cases in each group. Four parameters were considered, i) Age distribution, ii) Gender distribution, iii) Duration of normalization of stool consistency and iv) Duration of diarrhea Results: Age distribution was 56% (n=84) in Group-1 and 51. 33% (n=77) in Group-2 were between 0.5-6 years of age while 44% (n=66) in Group-1 and 48.67% (n=73) were between 7-12 years of age, mean+sd was calculated as 6.04+3.49 and 6.48+3.66 years respectively, Gender distribution was 60.67% (n=91) in Group=1 and 62.67% (n=94) in Group-2 were male while 39.33% (n=59) in Group-1 and 37.33% (n=56) in Group-2 were females. Duration of normalization of stools consistency was 44.24+2.63 hours in Group-1 and 71.56+2.48 hours in Group-2 was recorded, p value was calculated as 0.0001 which shows a significant difference between the two groups. Duration of diarrhea was recorded as60.58+3.70 hours in Group-1 and 88.76+4.02 hours in Group-2, p value was calculated as 0.0001 which shows a significant difference between the two groups. Conclusion: We concluded that administration of diosmectite in children with acute gastroenteritis shows a significant efficacy as compared to placebo with regards to mean duration of diarrhea and normalization of consistency of stools.

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