Shaheen Parveen, Huma Ali, Maria Sodagar, Amber Nawab, Anum Tariq, Fozia Israr.
Statistical Assessment of Drug Release Kinetics and Formulations Attributes of Ranitidine Tablets Available in Karachi, Pakistan.
Ann Jinnah Sindh Med Uni Jan ;5(1):3-9.

Objective: To elucidate the in vitro equivalence of Ranitidine brands with other quality attributes to provide drug fate for interchangeability or replacement during prescription writing Methodology: In the present study, quality assessment including range of physico-chemical parameters were evaluated for six selected brands of ranitidine (RT-1 to RT-6). Result: Results were observed to be in satisfactory points of confinement. Additionally, disintegration profiles of all brands were resolved utilizing phosphate buffer pH 6.8. Information was investigated by factual strategies as recommended by FDA, for example, similarity factor (f2) and difference factor (f1) and one-way ANOVA technique. Consequences of one-way ANOVA showed no huge variation among the dissolution profiles of reference and test brands. Conclusion: Correspondingly, results of f1 and f2 showed similar profiles of test and reference products. In addition, all the brands were found to be best fitted in Weibull model.

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