Huma Shareef, Erum Zaheer, Saima Abedin, Hina Hassam.
Phytomedicine: Silybum marianum (Silymarin) as an Effective Hepato-protective Source from Nature.
Ann Jinnah Sindh Med Uni Jan ;5(1):39-46.

Objective: To review the efficacy and safety of milk thistle for management of hepatic disorders Methodology: A thorough literature survey was carried out for the article. Following key words (Silybum marianum, Liver) were used to search the articles on Google Scholar and PubMed. More than 50 articles published between 2000 and 2018 were taken into consideration. Result: The review explored the main constituents of milk thistle and its properties to protect liver against various toxins, alcohol effects, and viral attacks. Silymarin is capable of regenerating liver and bring the hepatic markers, Alanine transaminase (ALT), Aspartate transaminase (AST) and others, to normal levels. Reported toxicities of silymarin are few. Conclusion: Silybum marianum has proved its higher efficacy and safety in hepatic disorders, as compared to other therapies and therefore is an agent of choice. Furthermore, its cost effectiveness and ability to be developed as various dosage forms, like emulsion and nanoparticles, undoubtedly ensures its extensive use in future.

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